Investigating the link between Down syndrome and acute lymphoblastic leukemia in children
Molecular epidemiology of acute lymphoblastic leukemia in children with Down syndrome
This study is looking into why kids with Down syndrome are more likely to get a type of blood cancer called acute lymphoblastic leukemia, and it hopes to find out how their genes play a role in this so that we can help keep them healthier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10908747 on NIH RePORTER |
What this research studies
This research focuses on understanding why children with Down syndrome are at a significantly higher risk of developing acute lymphoblastic leukemia (ALL). It aims to explore the genetic and phenotypic factors that contribute to this increased risk, particularly looking at the role of chromosome 21 and other genetic modifiers. By conducting genome-wide association studies, the research seeks to identify specific genetic loci that may influence leukemia susceptibility in these children. The findings could lead to better risk assessment and targeted interventions for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have been diagnosed with acute lymphoblastic leukemia and have Down syndrome.
Not a fit: Patients who do not have Down syndrome or who are outside the age range of 0-11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for children with Down syndrome who develop acute lymphoblastic leukemia.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors related to leukemia in children, but this specific focus on Down syndrome and ALL is relatively novel.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Rabin, Karen R — Baylor College of Medicine
- Study coordinator: Rabin, Karen R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.