Investigating the link between depression and Alzheimer's disease risk
Depression treatment and Aβ dynamics: A study of Alzheimer’s disease risk
This study is looking at how depression might affect the chances of developing Alzheimer's disease by checking the levels of certain proteins in the brain, and it's for adults over 21 who are dealing with depression to help understand how their mood might relate to their brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10889158 on NIH RePORTER |
What this research studies
This research explores how depression may influence the risk of developing Alzheimer's disease by examining the dynamics of amyloid-beta (Aβ) proteins in the brain. It focuses on adults over 21, particularly those experiencing depression, to understand how changes in Aβ levels relate to depression severity. The study utilizes various depression rating scales and analyzes cerebrospinal fluid and plasma samples to uncover potential causal relationships. By identifying these connections, the research aims to provide insights into how managing depression could impact Alzheimer's disease risk.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults over 21 who are experiencing symptoms of depression, particularly those without significant cognitive decline.
Not a fit: Patients who do not have depression or those already diagnosed with significant cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for reducing Alzheimer's disease risk through the treatment of depression.
How similar studies have performed: Previous studies have shown promising results in understanding the relationship between depression and Alzheimer's risk, suggesting that this research builds on established findings.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Pomara, Nunzio — New York University School of Medicine
- Study coordinator: Pomara, Nunzio
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.