Investigating the link between COVID-19 and Alzheimer's disease
Alzheimer's Disease and Related Dementia-like Sequelae of SARS-CoV-2 Infection: Virus-Host Interactome, Neuropathobiology, and Drug Repurposing
['FUNDING_OTHER'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-10661931
This study is looking at how COVID-19 might affect the brain and lead to Alzheimer's and other memory problems, and it's for anyone interested in understanding how the virus could impact brain health and finding new ways to help those who are struggling with these issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10661931 on ClinicalTrials.gov |
What this research studies
This research explores how SARS-CoV-2 infection may contribute to the development of Alzheimer's disease and related dementias. By examining the interactions between the virus and human proteins, the study aims to uncover the underlying mechanisms of neuroinflammation and brain injury associated with COVID-19. Using advanced techniques, including patient-derived stem cells, researchers will analyze brain cells to identify potential drug targets and pathways that could mitigate cognitive decline. The goal is to provide insights that could lead to new treatments for those affected by both COVID-19 and neurocognitive disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced COVID-19 and are showing signs of cognitive impairment or are at risk for Alzheimer's disease.
Not a fit: Patients who have not had COVID-19 or do not exhibit any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to prevent or treat Alzheimer's disease in patients who have had COVID-19.
How similar studies have performed: Other research has indicated potential links between viral infections and neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHENG, FEIXIONG — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: CHENG, FEIXIONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease