Investigating the link between clonal hematopoiesis and heart disease in post-menopausal women
Clonal Hematopoiesis in the Women's Health Initiative
This study is looking at how a condition called clonal hematopoiesis of indeterminate potential (CHIP) might affect heart health, especially in post-menopausal women, by using information from a large health study to see if CHIP is linked to heart problems like heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11064067 on NIH RePORTER |
What this research studies
This research focuses on clonal hematopoiesis of indeterminate potential (CHIP), a condition where mutations in blood stem cells lead to the overgrowth of certain blood cell clones. It aims to explore how CHIP may contribute to heart diseases, particularly heart failure with preserved ejection fraction (HFpEF), in post-menopausal women. By utilizing data from the Women's Health Initiative, which includes a large and diverse group of participants, the study will examine various factors that may influence the progression of CHIP and its relationship with cardiovascular health. The research will involve extensive data analysis and follow-up to understand the long-term effects of CHIP on heart health.
Who could benefit from this research
Good fit: Ideal candidates for this research are post-menopausal women who may be at risk for heart disease and have a history of clonal hematopoiesis.
Not a fit: Patients who are not post-menopausal or do not have clonal hematopoiesis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of heart disease in post-menopausal women, potentially reducing the risk of heart failure.
How similar studies have performed: Previous research has indicated a connection between clonal hematopoiesis and cardiovascular diseases, suggesting that this approach has potential for meaningful insights.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Reiner, Alexander P — Fred Hutchinson Cancer Center
- Study coordinator: Reiner, Alexander P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.