Investigating the link between circadian rhythms and Alzheimer's disease in older adults
Circadian Rest-Activity Rhythms, Metabolomic Profiles, and Incidence of Alzheimer's Disease and Related Dementia in Older Men and Women
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-10629182
This study is looking at how changes in our body's natural sleep-wake cycle might be linked to Alzheimer's disease in older adults, and it aims to find out if certain patterns in daily activity and metabolism can help us understand this connection better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10629182 on ClinicalTrials.gov |
What this research studies
This research explores how disruptions in the body's internal clock, known as circadian rhythms, may contribute to the development of Alzheimer's disease and related dementias in older adults. By examining metabolic profiles and activity patterns, the study aims to identify biological mechanisms that connect circadian disruption with cognitive decline. Participants will be monitored for their rest-activity patterns and undergo metabolomic analysis to uncover potential metabolic changes associated with Alzheimer's risk. The findings could lead to new insights into modifiable risk factors for dementia.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those experiencing changes in sleep patterns or cognitive function.
Not a fit: Patients who are not elderly or do not exhibit any signs of cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or delaying the onset of Alzheimer's disease and related dementias.
How similar studies have performed: Previous studies have shown promising results in linking circadian rhythm disruptions to cognitive decline, suggesting that this approach may yield valuable insights.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XIAO, QIAN — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: XIAO, QIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.