Investigating the link between antibiotic use, high birth weight, and early-onset colorectal cancer
Official title: A Case-Control Study to Evaluate Broad-Spectrum Antibiotic use and High Birth Weight as Potential Risk Factors for Early-Onset Colorectal Cancer
Funded at Kaiser Foundation Research Institute · NIH-10687185 · Data updated 2026-11-12
This study is looking at how certain factors, like taking antibiotics and being born with a high birth weight, might increase the risk of colorectal cancer in young adults under 50, and it’s inviting people to share their health and lifestyle information to help us understand this better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kaiser Foundation Research Institute NIH-funded |
| Lab location | 1 site (Oakland, UNITED STATES) |
| Project start | September 15, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $360,475 |
| NIH project number | 5R01CA258160-03 |
| Project ID | NIH-10687185 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include young adults under 50 who have experienced high birth weight or have a history of broad-spectrum antibiotic use.
✕Less likely to help
Patients who are over 50 years old or do not have a history of the specified risk factors may not benefit from this research.
What this research studies
This research aims to explore potential risk factors for early-onset colorectal cancer (eoCRC) in young adults under 50, focusing on the impact of broad-spectrum antibiotic use and high birth weight. By analyzing data from diverse populations, the study seeks to identify how these factors may contribute to the rising incidence of eoCRC. Participants may provide information about their medical history, lifestyle, and early life exposures, which will be used to develop a better understanding of the disease's etiology. The findings could lead to improved screening and prevention strategies for at-risk individuals.
Why it matters
Potential benefit: If successful, this research could lead to better identification of individuals at risk for early-onset colorectal cancer and inform preventive measures.
How similar studies have gone: While there is limited research specifically on early-onset colorectal cancer, studies on gut microbiome and antibiotic use have shown promising results in understanding various gastrointestinal diseases.
Where this research is happening
-
Kaiser Foundation Research Institute
Oakland, United States Active
Researchers
- Principal investigator: Chao, Chun R. — Kaiser Foundation Research Institute
- Study coordinator: Chao, Chun R.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.