Investigating the link between a specific genetic element and Alzheimer's Disease
Establishment of a causal link between AD and L1 retrotransposons
This study is looking at how certain genetic elements might play a role in the development of Alzheimer's Disease by examining brain cells from both healthy people and those with the disease, which could help us understand more about Alzheimer's and find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10886046 on NIH RePORTER |
What this research studies
This research aims to explore how L1 retrotransposons, which are genetic elements, may contribute to the development of Alzheimer's Disease (AD). By using induced pluripotent stem cells from both healthy individuals and AD patients, the researchers will analyze the effects of L1 expression on brain cells. The study will focus on understanding how L1 might trigger inflammation and affect neuronal health, potentially leading to AD pathology. This could provide insights into the underlying mechanisms of AD and identify new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's Disease as well as healthy controls for comparison.
Not a fit: Patients with other forms of dementia or neurological disorders unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's Disease.
How similar studies have performed: While the role of L1 retrotransposons in other diseases has been studied, this specific investigation into their causal link with Alzheimer's Disease is relatively novel.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Muotri, Alysson R. — University of California, San Diego
- Study coordinator: Muotri, Alysson R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.