Investigating the impact of vitamin K on knee function in adults with osteoarthritis
Effects of Vitamin K on Lower-extremity Function in Adults with Osteoarthritis: a Randomized Controlled Pilot Trial
This study is looking at whether taking vitamin K can help improve movement and joint health for adults with knee osteoarthritis, and it’s a friendly way to see if this could be helpful for people who might need more support with their knee issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10708005 on NIH RePORTER |
What this research studies
This research explores how vitamin K supplementation may improve lower-extremity function in adults suffering from knee osteoarthritis (OA). Participants will be involved in a randomized controlled pilot trial, where they will receive either vitamin K or a placebo to assess its effects on their mobility and joint health. The study aims to gather data on the feasibility of conducting a larger clinical trial in the future, focusing on adults with mild to moderate knee OA and low vitamin K levels. By understanding the role of vitamin K in joint health, the research seeks to identify effective strategies to alleviate disability associated with knee OA.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have been diagnosed with mild to moderate knee osteoarthritis and have low baseline levels of vitamin K.
Not a fit: Patients with severe knee osteoarthritis or those who do not have low vitamin K levels may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new dietary recommendations or treatments that improve mobility and quality of life for individuals with knee osteoarthritis.
How similar studies have performed: While there is emerging evidence supporting the role of vitamin K in joint health, this specific approach has not yet been tested in clinical trials.
Where this research is happening
Boston, United States
- Tufts University Boston — Boston, United States (Active)
Researchers
- Principal investigator: Booth, Sarah Louise — Tufts University Boston
- Study coordinator: Booth, Sarah Louise
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.