Investigating the impact of PFAS chemicals on liver health and developing solutions for contamination.
Official title: Southern California Superfund Research and Training Program for PFAS Assessment, Remediation, and Prevention (ShARP)
Funded at University of Southern California · NIH-10939225 · Data updated 2026-11-12
This study is looking at how certain chemicals in our water can affect liver health, and it's for anyone interested in understanding the risks of these substances and how we can better protect ourselves and our environment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | April 24, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $1,632,022 |
| NIH project number | 1P42ES036506-01 |
| Project ID | NIH-10939225 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include individuals living near contaminated sites or those with liver health concerns potentially linked to PFAS exposure.
✕Less likely to help
Patients who do not reside in areas affected by PFAS contamination or who do not have liver health issues may not benefit from this research.
What this research studies
This research focuses on understanding how poly- and perfluoroalkyl substances (PFAS) contaminate water sources and their effects on liver health. By utilizing advanced techniques, the project aims to evaluate PFAS exposure through human studies and innovative 3D liver models. The research will also develop new methods for detecting PFAS in the environment and create predictive models for groundwater contamination. Patients may benefit from improved understanding and potential interventions for liver diseases linked to PFAS exposure.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for liver diseases associated with PFAS exposure.
How similar studies have gone: Previous research has shown promising results in addressing environmental contaminants and their health impacts, indicating potential for success in this novel approach.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Chatzi, Vaia Lida — University of Southern California
- Study coordinator: Chatzi, Vaia Lida
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.