Investigating the impact of MYC mutations in acute myeloid leukemia
The Role of MYC Mutations in acute Myeloid Leukemia
This study is looking at how certain changes in the MYC gene affect the behavior of acute myeloid leukemia (AML) cells, with the hope of finding better treatments that are tailored to individual patients based on their unique genetic makeup.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10906677 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific mutations in the MYC gene affect the behavior of acute myeloid leukemia (AML) cells. By examining these mutations and their interactions with other genetic factors, the study aims to uncover the biological differences in AML cases. The research utilizes advanced techniques to manipulate gene expression in laboratory settings, allowing for a detailed analysis of how these mutations influence treatment outcomes and disease progression. Patients may benefit from insights gained that could lead to more effective therapies tailored to their specific genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with acute myeloid leukemia, particularly those with MYC mutations.
Not a fit: Patients with other types of leukemia or those without MYC mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with acute myeloid leukemia based on their unique genetic mutations.
How similar studies have performed: Previous research has shown promising results in understanding the role of genetic mutations in leukemia, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Ferraro, Francesca — Washington University
- Study coordinator: Ferraro, Francesca
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.