Investigating the impact of muscle fat on brain health in older adults of African ancestry
Myosteatosis, Cognition and Blood Biomarkers of Alzheimer's Disease in Persons of African Ancestry
This study is looking at how fat buildup in muscles might affect brain health and the risk of Alzheimer's and related conditions in older adults of African ancestry, and it aims to find new clues about cognitive decline by checking body composition and brain function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10447294 on NIH RePORTER |
What this research studies
This research focuses on understanding how fat accumulation in muscles, known as myosteatosis, affects cognitive health and the risk of Alzheimer's Disease and Related Dementias (ADRD) in older adults of African ancestry. The study aims to explore the relationship between myosteatosis and various biological markers associated with ADRD, while also considering the role of beneficial substances released by muscles, called myokines. By examining these factors, the research seeks to identify new risk factors for cognitive decline that are particularly relevant to this population. Participants may undergo assessments of body composition and cognitive function to contribute to this important investigation.
Who could benefit from this research
Good fit: Ideal candidates for participation are older adults of African ancestry who are 21 years or older and may be at risk for Alzheimer's Disease or related dementias.
Not a fit: Patients who are not of African ancestry or those who do not have concerns related to cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and strategies for preventing or mitigating cognitive decline in older adults of African ancestry.
How similar studies have performed: While the specific focus on myosteatosis in this population is novel, previous research has indicated that fat distribution and its effects on health are important areas of study, suggesting potential for meaningful findings.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Miljkovic, Iva — University of Pittsburgh at Pittsburgh
- Study coordinator: Miljkovic, Iva
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.