Investigating the impact of genetic testing on blood pressure and pain management in African Americans
Official title: IGNITE EP2 - Admin Supplement
Funded at University of Florida · NIH-11075489 · Data updated 2026-11-12
This study is looking at how testing for a specific gene can help African Americans with high blood pressure and pain get better treatment tailored just for them, by comparing different ways of sharing test results and how they affect their care.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $258,184 |
| NIH project number | 3U01HG007269-09S3 |
| Project ID | NIH-11075489 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are African American adults aged 21 and older who have hypertension, with or without chronic kidney disease.
✕Less likely to help
Patients who do not identify as African American or those without hypertension may not receive benefit from this research.
What this research studies
This research focuses on understanding how genetic testing for the APOL1 gene can influence the management of hypertension and pain in African Americans. The study involves two clinical trials: GUARDD-US, which examines the effects of immediate versus delayed genetic testing results on blood pressure control, and ADOPT PGx, which explores the role of pharmacogenetic testing in pain management. Participants will be African Americans with hypertension, and the trials aim to provide insights into personalized treatment approaches based on genetic information.
Why it matters
Potential benefit: If successful, this research could lead to improved blood pressure management and pain treatment strategies tailored to the genetic profiles of African American patients.
How similar studies have gone: Previous research has shown promising results in using genetic testing to guide treatment decisions, particularly in populations at higher risk for certain conditions.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Cavallari, Larisa Humma — University of Florida
- Study coordinator: Cavallari, Larisa Humma
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.