Investigating the impact of false positive results in lung cancer screening
Official title: Lung Cancer Screening: Cumulative Risk and Multilevel Impact of False Positive Findings
Funded at Univ of North Carolina Chapel Hill · NIH-10980096 · Data updated 2026-11-12
This study is looking at how false alarms from lung cancer screenings can affect patients and the healthcare system, and it aims to find ways to reduce these false alarms so that everyone can have better conversations about their health and get the most out of their screenings.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | July 18, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $657,536 |
| NIH project number | 1R01CA285976-01A1 |
| Project ID | NIH-10980096 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 50-80 who are current or former smokers with a significant smoking history.
✕Less likely to help
Patients who do not meet the age or smoking history criteria may not benefit from this research.
What this research studies
This research focuses on understanding the effects of false positive findings in lung cancer screening using low-dose computed tomography (LDCT). It aims to assess the burden these false positives place on patients, healthcare providers, and the healthcare system as a whole. By analyzing data from multiple rounds of screening, the study seeks to identify factors that contribute to false positives and develop strategies to minimize their occurrence. This will help improve patient-clinician discussions and optimize the benefits of lung cancer screening.
Why it matters
Potential benefit: If successful, this research could lead to improved lung cancer screening protocols that reduce unnecessary anxiety and invasive procedures for patients.
How similar studies have gone: Previous research has indicated the challenges associated with false positives in cancer screening, suggesting that addressing this issue could lead to significant improvements in patient care.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Henderson, Louise — Univ of North Carolina Chapel Hill
- Study coordinator: Henderson, Louise
Related research
Other NIH-funded projects on the same topics.
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Digital health strategies to expand lung cancer screening in safety-net clinics
A funded project aims to help low-resource clinics increase the use of lung cancer screening for patients who smoke or are at risk.
-
Integrated approach to lung screening and quitting for African Americans
A multi-level program aims to boost LDCT lung cancer screening uptake and help African American smokers quit, with support from a comprehensive community-focused plan.
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Population health approach to boost lung cancer screening at community clinics
A large Utah project aims to help community clinics reach more eligible adults to get low-dose CT lung cancer screening.
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Group-based tobacco treatment for older adults after lung cancer screening
A study tests a group-based tobacco cessation program for older adults who are getting lung cancer screening to help them quit smoking.
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Personalized Lung Cancer Screening for Veterans
Aimed at improving who gets screened and how lung cancer is diagnosed among Veterans using personalized tools.
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Proteogenomic framework to improve lung cancer screening with biomarkers
A biomarker-based approach aims to refine LDCT lung cancer screening so more cancers are caught early while reducing unnecessary procedures.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.