Investigating the immune response and blood clotting issues in severe COVID-19 cases
Official title: B-cell response and thrombotic complications in COVID-19
Funded at Versiti Wisconsin, INC. · NIH-11030764 · Data updated 2026-11-12
This study is looking at how the immune system reacts to the COVID-19 virus and why some people get really sick with blood clots, hoping to find ways to improve treatments for everyone affected by the virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Versiti Wisconsin, INC. NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | February 1, 2022 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $593,885 |
| NIH project number | 5R01HL161127-04 |
| Project ID | NIH-11030764 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with severe COVID-19 who are experiencing significant inflammatory and thrombotic complications.
✕Less likely to help
Patients with mild COVID-19 symptoms or those who have fully recovered from the virus may not benefit from this research.
What this research studies
This research focuses on understanding how the immune system's response to the SARS-CoV-2 virus can lead to severe complications, particularly blood clotting issues. It examines the differences in immune responses between patients with mild and severe COVID-19, specifically looking at the role of B-cells and antibodies. By analyzing blood samples, the study aims to uncover the mechanisms linking inflammation and thrombosis in these patients, which could lead to better treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of thrombotic complications in COVID-19 patients.
How similar studies have gone: Previous research has indicated a connection between immune responses and thrombotic events in COVID-19, suggesting that this approach has potential for success.
Where this research is happening
-
Versiti Wisconsin, INC.
Milwaukee, United States Active
Researchers
- Principal investigator: Wen, Renren — Versiti Wisconsin, INC.
- Study coordinator: Wen, Renren
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.