Investigating the human pancreas to understand type 2 diabetes
Official title: Human Pancreas Analysis Program-T2D
Funded at Vanderbilt University Medical Center · NIH-10907128 · Data updated 2026-11-12
This study is looking at how type 2 diabetes affects the pancreas by examining tissue samples from people at different stages of the disease, including those with prediabetes and those managing their diabetes with diet, medication, or insulin, to help us better understand what causes the condition and how it works.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | September 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $350,000 |
| NIH project number | 3U01DK123716-04S1 |
| Project ID | NIH-10907128 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with prediabetes, type 2 diabetes managed with diet or medications, and those treated with insulin.
✕Less likely to help
Patients with type 1 diabetes or those without any form of diabetes may not benefit from this research.
What this research studies
This research focuses on understanding the molecular mechanisms behind type 2 diabetes (T2D) by analyzing human pancreatic tissue and islets from individuals at different stages of the disease. The team will collect samples from donors with prediabetes, T2D managed with diet or medications, and those treated with insulin, as well as normal controls. Using advanced molecular techniques and new experimental approaches, they aim to identify genetic risks and characterize changes in pancreatic islet function and tissue architecture. This comprehensive analysis will help uncover the underlying causes of T2D and improve our understanding of the disease.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for type 2 diabetes.
How similar studies have gone: Similar research approaches have shown promise in understanding diabetes mechanisms, indicating potential for success in this investigation.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Powers, Alvin C — Vanderbilt University Medical Center
- Study coordinator: Powers, Alvin C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.