Investigating the human pancreas to understand type 2 diabetes
Human Pancreas Analysis Program-T2D
['FUNDING_U01'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-10907128
This study is looking at how type 2 diabetes affects the pancreas by examining tissue samples from people at different stages of the disease, including those with prediabetes and those managing their diabetes with diet, medication, or insulin, to help us better understand what causes the condition and how it works.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-10907128 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the molecular mechanisms behind type 2 diabetes (T2D) by analyzing human pancreatic tissue and islets from individuals at different stages of the disease. The team will collect samples from donors with prediabetes, T2D managed with diet or medications, and those treated with insulin, as well as normal controls. Using advanced molecular techniques and new experimental approaches, they aim to identify genetic risks and characterize changes in pancreatic islet function and tissue architecture. This comprehensive analysis will help uncover the underlying causes of T2D and improve our understanding of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with prediabetes, type 2 diabetes managed with diet or medications, and those treated with insulin.
Not a fit: Patients with type 1 diabetes or those without any form of diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for type 2 diabetes.
How similar studies have performed: Similar research approaches have shown promise in understanding diabetes mechanisms, indicating potential for success in this investigation.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: POWERS, ALVIN C — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: POWERS, ALVIN C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Diabetes Mellitus