Investigating the HIV-related effects of opioids on the body.
The HIV-associated Opioid Micro-Environment (HOME) Project
The HOME Project is looking at how opioids might influence HIV in the body by studying samples from people with HIV who are on treatment, helping us understand how these substances affect HIV levels and the immune system.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10056153 on NIH RePORTER |
What this research studies
The HOME Project aims to understand how opioids affect HIV reservoirs in the body by analyzing various tissues and fluids from individuals with HIV who are on antiretroviral therapy. This research utilizes a unique cohort that collects samples before and shortly after death, allowing for a comprehensive examination of HIV's presence in hard-to-reach anatomical sites. By employing advanced technologies, the project seeks to characterize the size and activity of HIV reservoirs and the diversity of T cells in relation to opioid levels. This innovative approach could provide insights into the interplay between substance use and HIV persistence.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on suppressive antiretroviral therapy and have a history of opioid use.
Not a fit: Patients who are not living with HIV or who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for eradicating HIV from the body, particularly in individuals with a history of opioid use.
How similar studies have performed: Previous research has shown promise in understanding HIV reservoirs, but the specific approach of this project is innovative and largely untested.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Gianella Weibel, Sara — University of California, San Diego
- Study coordinator: Gianella Weibel, Sara
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.