Investigating the hidden sources of HIV in blood stem cells
Cellular Reservoirs of HIV
This study is looking into why HIV can stick around in the body even when people are taking their medications, focusing on special blood cells that can hide the virus and keep it from being completely cleared out.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10721411 on NIH RePORTER |
What this research studies
This research focuses on understanding how HIV persists in the body despite treatment with antiretroviral medications. It examines CD4+ hematopoietic stem and progenitor cells, which can survive for a long time and are capable of being infected by HIV. The researchers aim to identify the cellular reservoirs that harbor the virus and contribute to ongoing infection, even when patients are on effective therapy. By developing a model to study these cells, the research seeks to uncover mechanisms that allow HIV to evade eradication.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy but still have detectable viral reservoirs.
Not a fit: Patients who are not infected with HIV or those who have not responded to antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for eradicating HIV from the body, potentially offering a cure for those living with the virus.
How similar studies have performed: Previous studies have shown promise in understanding HIV reservoirs, but this research aims to explore novel aspects of the virus's persistence that have not been fully tested.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Collins, Kathleen L. — University of Michigan at Ann Arbor
- Study coordinator: Collins, Kathleen L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.