Investigating the hepatitis B virus capsid to find new antiviral treatments
Molecular dynamics of the HBV capsid to advance the search for antivirals
This study is looking at a part of the hepatitis B virus to find new ways to stop it from growing, which could lead to better treatments for people living with hepatitis B.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Delaware NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11185622 on NIH RePORTER |
What this research studies
This research focuses on the hepatitis B virus (HBV) capsid, which is a potential target for new antiviral therapies. The project utilizes advanced computational techniques, specifically molecular dynamics simulations, to explore the various conformations of the capsid proteins. By identifying small molecules that can disrupt the assembly of the capsid, the research aims to develop effective inhibitors that could lead to new treatments for HBV. Patients may benefit from this work as it seeks to advance the development of antiviral drugs that could eliminate viral hepatitis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic hepatitis B virus infections who are seeking new treatment options.
Not a fit: Patients with hepatitis C or other unrelated viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral drugs that effectively treat hepatitis B virus infections.
How similar studies have performed: While the approach of targeting the HBV capsid is promising, it is relatively novel and has not yet been widely tested in clinical settings.
Where this research is happening
Newark, UNITED STATES
- University of Delaware — Newark, United States (Active)
Researchers
- Principal investigator: Hadden-Perilla, Jodi a — University of Delaware
- Study coordinator: Hadden-Perilla, Jodi a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.