Investigating the health effects of switching from smoking to non-combusted tobacco products
Airway Biomarker Based Assessment of Combusted to Non-Combusted Tobacco Use Transition Effects
This study is looking at how switching from regular cigarettes to e-cigarettes might affect your lung health, by comparing samples from current smokers, former smokers, and e-cigarette users to see if there are any changes in harmful substances in the airways.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10692703 on NIH RePORTER |
What this research studies
This research aims to analyze the health impacts of transitioning from combusted tobacco products, like cigarettes, to non-combusted alternatives, such as electronic nicotine delivery systems (ENDS). By examining biobanked bronchoalveolar lavage samples from various groups, including current smokers, former smokers, and ENDS users, the study will assess changes in airway biomarkers. The goal is to determine whether these non-combusted products lead to reduced airway toxicity and identify specific biomarkers associated with this transition. This research could provide valuable insights into the safety and health implications of using ENDS compared to traditional smoking.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have switched from smoking to using electronic nicotine delivery systems, as well as current and former smokers.
Not a fit: Patients who have never used tobacco products or those who exclusively use combusted tobacco without transitioning may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could help clarify the health benefits of switching to non-combusted tobacco products, potentially guiding public health recommendations.
How similar studies have performed: Previous studies have indicated that transitioning to ENDS can lead to distinct changes in airway biomarkers, suggesting that this research builds on promising findings in the field.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Reidel, Boris — Univ of North Carolina Chapel Hill
- Study coordinator: Reidel, Boris
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.