Investigating the gut's immune response in Lewy Body Disease
Official title: Role of altered gut immune response in Lewy Body Disease
Funded at Stanford University · NIH-10988065 · Data updated 2026-11-12
This study is looking at how the bacteria in our gut and our immune system might be linked to conditions like Parkinson's Disease and Lewy body dementia, with the hope of finding new ways to help people with these diseases.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $465,704 |
| NIH project number | 1U01DK140939-01 |
| Project ID | NIH-10988065 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Lewy Body Diseases or those showing early signs, such as isolated REM Sleep Behavior Disorder.
✕Less likely to help
Patients with Lewy Body Diseases who do not have any gastrointestinal symptoms or immune system involvement may not benefit from this research.
What this research studies
This research explores the connection between the gut microbiota and immune system in patients with Lewy Body Diseases, such as Parkinson's Disease and dementia with Lewy bodies. It aims to understand how changes in the gut and immune responses may contribute to the progression of these neurological disorders. By utilizing advanced technologies, the study will analyze various biological parameters in patients, including those with early signs of Lewy Body Disease. The goal is to uncover potential pathways that could lead to new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapies that improve the management of Lewy Body Diseases.
How similar studies have gone: While the interplay between gut health and neurological diseases is an emerging field, this specific approach is relatively novel and has not been extensively tested in the context of Lewy Body Diseases.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Poston, Kathleen Lombard — Stanford University
- Study coordinator: Poston, Kathleen Lombard
Related research
Other NIH-funded projects on the same topics.
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Gut-immune changes in Lewy Body Diseases and early signs
A study at Stanford will explore how the gut and its immune system may be linked to Lewy Body diseases like Parkinson’s and related conditions, with findings that could point to new ways to understand and someday treat these illnesses.
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Gut-immune system links in Lewy Body Disease
Researchers are studying how the gut and immune system may influence Lewy body diseases like Parkinson’s and dementia with Lewy bodies, aiming to uncover new clues that could lead to better diagnosis and treatment in the future.
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Amygdala’s role in Lewy body disease and Alzheimer’s disease
A clinician-science training grant to help Dr. D. Luke Fischer study how the amygdala may drive the spread of disease in people with Lewy body disease and Alzheimer’s disease.
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Gut immune changes in Lewy body disorders
This project looks at whether changes in gut immune signals and gut bacteria are linked to Parkinson's disease, dementia with Lewy bodies, and people with early signs like REM sleep behavior disorder.
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Automated Neurodegeneration Index for Lewy Body Disease in At-Risk Groups
A new machine‑learning tool analyzes routine brain scans to identify early neurodegeneration in people at risk for Parkinson’s disease or dementia with Lewy bodies.
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Identifying molecules that interact with alpha-synuclein in Alzheimer's disease–related dementias
A study at Mayo Clinic Jacksonville will map which proteins interact with alpha-synuclein in brain tissue and human-derived cells to understand its role in dementia like Lewy body disease and Alzheimer’s-related dementias.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.