Investigating the gut microbiome's role in colorectal adenoma formation and progression
The gut microbiome, interactions with primed colon states, and effects on adenoma formation and progression
This study is looking at how the bacteria in our gut might affect early signs of colon cancer, specifically in Alaska Native people, to find ways to predict and prevent these early growths called adenomas without needing invasive tests.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11187481 on NIH RePORTER |
What this research studies
This research explores how the gut microbiome interacts with precancerous conditions in the colon, specifically focusing on colorectal adenomas, which are early indicators of colorectal cancer. By studying the gut microbiomes of the Alaska Native population, the research aims to identify specific microbial biomarkers that could help predict the formation of these adenomas. The project involves collaboration between the Fred Hutch Cancer Center and the Alaska Native Tribal Health Consortium to develop non-invasive screening methods and potential microbiome-based interventions for adenoma prevention.
Who could benefit from this research
Good fit: Ideal candidates for this research include Alaska Native individuals who are at risk for colorectal adenomas or colorectal cancer.
Not a fit: Patients who do not belong to the Alaska Native population or those without risk factors for colorectal adenomas may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved screening and prevention strategies for colorectal cancer, particularly in high-risk populations.
How similar studies have performed: While there is emerging evidence linking the gut microbiome to colorectal cancer, this specific approach targeting the Alaska Native population is novel and has not been extensively tested.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Dey, Neelendu — Fred Hutchinson Cancer Center
- Study coordinator: Dey, Neelendu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.