Investigating the giant protein titin's role in heart health and disease
Role of the giant protein titin in cardiac health and disease
This study is looking at a big protein called titin to see how it helps keep our hearts healthy and how changes in it might lead to heart problems, with the goal of finding new treatments that could help improve heart function for people with heart disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-11081723 on NIH RePORTER |
What this research studies
This research explores the function of titin, the largest known protein, in maintaining heart health and its involvement in various heart diseases. It aims to understand how titin contributes to heart conditions like heart failure with preserved and reduced ejection fraction. The study will utilize advanced techniques to analyze the structural changes in titin and how these changes affect heart function. Additionally, it will involve drug screening to identify potential treatments that can modify titin's behavior to improve heart function.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with heart failure, particularly those with preserved or reduced ejection fraction.
Not a fit: Patients without any cardiac conditions or those with non-cardiac related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for heart failure, improving the quality of life for patients with cardiac conditions.
How similar studies have performed: Previous studies have shown promising results in understanding titin's role in heart disease, indicating that this research builds on established findings rather than being entirely novel.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Granzier, Henk L. — University of Arizona
- Study coordinator: Granzier, Henk L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.