Investigating the genetics of exceptional longevity and healthy aging.
The Long Life Family Study
The Long Life Family Study is looking for clues about why some families live longer and healthier lives by studying nearly 5,000 people from families known for their longevity, hoping to find special genes that help protect against diseases like Alzheimer's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10616710 on NIH RePORTER |
What this research studies
The Long Life Family Study focuses on understanding the genetic factors that contribute to exceptional longevity and healthy aging. By enrolling nearly 5,000 participants from families known for their long lives, the research examines various health traits through extensive in-home assessments. The study aims to identify rare genetic variants that may protect against age-related diseases, including Alzheimer's disease, by conducting whole genome sequencing on this unique cohort. Participants will also undergo longitudinal assessments to track changes in health over time.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals from families with a history of exceptional longevity and those interested in the genetic factors influencing healthy aging.
Not a fit: Patients who do not have a family history of exceptional longevity or are not interested in genetic research may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic basis of healthy aging and potential interventions to improve longevity and reduce the risk of age-related diseases.
How similar studies have performed: Previous research has shown success in identifying genetic factors associated with longevity, making this study a continuation of promising findings in the field.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Province, Michael a. — Washington University
- Study coordinator: Province, Michael a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.