Investigating the genetics of Alzheimer's disease using human and fruit fly models
Functional Genomic Dissection of Alzheimer's Disease in Humans and Drosophila Models
['FUNDING_U01'] · BAYLOR COLLEGE OF MEDICINE · NIH-10873961
This study is looking at how our genes might play a role in Alzheimer's disease and related dementias, using both human data and fruit flies to find out which specific genes could affect your risk, with the hope that this could lead to new ways to prevent or treat the disease.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10873961 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the genetic factors that contribute to Alzheimer's disease (AD) and related dementias. By analyzing genetic data from humans and using fruit flies as experimental models, the study aims to identify specific genes and genetic variants that influence the risk of developing AD. The researchers will employ advanced computational methods and high-throughput screening techniques to validate their findings and explore how these genetic factors interact to affect brain health. Patients may benefit from insights that could lead to new prevention strategies or treatments for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals aged 21 and older who are at risk for or diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with non-genetic forms of dementia or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and potentially treating Alzheimer's disease.
How similar studies have performed: Other research has shown promise in using genetic approaches to understand complex diseases, suggesting that this methodology could yield valuable insights.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHULMAN, JOSHUA M — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: SHULMAN, JOSHUA M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia