Investigating the genetics of a vision loss condition called central serous chorioretinopathy.
Official title: Genetics of central serous chorioretinopathy and choroidal thickening
Funded at Massachusetts Eye and Ear Infirmary · NIH-11077874 · Data updated 2026-11-12
This study is looking at how our genes might affect central serous chorioretinopathy (CSC), a condition that can cause vision problems, and it’s for anyone interested in understanding more about the genetic links to this eye issue and its connection to age-related vision changes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Eye and Ear Infirmary NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 1, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $276,856 |
| NIH project number | 5K23EY035342-02 |
| Project ID | NIH-11077874 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include individuals diagnosed with central serous chorioretinopathy or those with a family history of the condition.
✕Less likely to help
Patients with other unrelated eye conditions or those who do not have a genetic predisposition to CSC may not benefit from this research.
What this research studies
This research focuses on understanding the genetic factors associated with central serous chorioretinopathy (CSC), a condition that can lead to progressive vision loss. The study aims to identify genetic variations linked to CSC and the thickness of the choroid, which is a layer of blood vessels in the eye. By examining these genetic associations, researchers hope to uncover new insights into the mechanisms of CSC and its relationship with age-related macular degeneration. The principal investigator will receive training in statistical genetics and advanced imaging techniques to enhance patient recruitment and data analysis.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential new treatments for patients suffering from central serous chorioretinopathy.
How similar studies have gone: Previous research has shown promising results in identifying genetic factors related to age-related macular degeneration, suggesting that this approach may yield valuable insights for CSC as well.
Where this research is happening
-
Massachusetts Eye and Ear Infirmary
Boston, United States Active
Researchers
- Principal investigator: Rossin, Elizabeth Jeffries — Massachusetts Eye and Ear Infirmary
- Study coordinator: Rossin, Elizabeth Jeffries
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.