Investigating the genetics and epigenetics of childhood germ cell tumors
Genetics and epigenetics of pediatric germ cell tumors
This study is looking at how genes and other factors affect germ cell tumors in kids, with the hope of finding ways to tailor treatments based on each child's unique genetic makeup to help them respond better to chemotherapy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10908312 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic and epigenetic factors that contribute to germ cell tumors in children. By analyzing DNA samples from patients and their tumors, the study aims to identify specific genetic variations and DNA methylation patterns that may influence treatment outcomes. The research will also explore how these factors can help in predicting which patients are at higher risk for poor responses to chemotherapy. Ultimately, the goal is to improve treatment strategies for pediatric germ cell tumors based on individual genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research include children diagnosed with germ cell tumors and their families who are willing to participate in genetic testing.
Not a fit: Patients with germ cell tumors who are not within the pediatric age range or those who do not have a genetic predisposition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for children with germ cell tumors.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors in adult germ cell tumors, suggesting that this approach may also be beneficial for pediatric cases.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Poynter, Jenny N. — University of Minnesota
- Study coordinator: Poynter, Jenny N.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.