Investigating the genetic factors that lead to chronic lymphocytic leukemia from its precursor state.
The genetic and epigenetic etiology of progression from the precursor state to chronic lymphocytic leukemia (CLL)
This study is looking at how certain genes might help us understand why some people with a condition called monoclonal B-cell lymphocytosis (MBL) might develop chronic lymphocytic leukemia (CLL) later on, especially focusing on African Americans, so we can find ways to better predict and prevent the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10914019 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain genetic and epigenetic factors contribute to the progression from monoclonal B-cell lymphocytosis (MBL), a precursor to chronic lymphocytic leukemia (CLL). By studying a large cohort of individuals, particularly African Americans, the research aims to identify biomarkers that can predict which individuals with MBL are at higher risk of developing CLL. This could lead to targeted prevention strategies and better management of the disease. The study will involve screening a significant number of African American individuals to establish a dedicated cohort for further analysis.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with monoclonal B-cell lymphocytosis, especially those who are African American or have a family history of CLL.
Not a fit: Patients who do not have monoclonal B-cell lymphocytosis or chronic lymphocytic leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for chronic lymphocytic leukemia, particularly in high-risk populations.
How similar studies have performed: Previous research has shown success in identifying genetic markers for other types of leukemia, suggesting potential for similar breakthroughs in this area.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Slager, Susan L — Mayo Clinic Rochester
- Study coordinator: Slager, Susan L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.