Investigating the genetic factors that influence resistance to parasites
A general test of the genetic basis of parasite resistance across genetic and environmental contexts
This study is looking at how our genes and surroundings help us fight off infections from parasites, using tiny worms to find out which specific genes make a difference, so we can better understand how to boost our resistance to these infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11082780 on NIH RePORTER |
What this research studies
This research focuses on understanding how genetic and environmental factors contribute to an individual's ability to resist infections caused by parasites. By using the model organism Caenorhabditis elegans, researchers will conduct experiments to identify specific genes associated with parasite resistance across different contexts. The study employs advanced techniques such as high-throughput phenotyping and experimental evolution to analyze genetic variation and the effects of different parasite strains. This approach aims to provide insights into the complex interactions between genetics and environmental factors in disease resistance.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a genetic predisposition to infectious diseases or those interested in understanding their genetic risk factors.
Not a fit: Patients who do not have a genetic basis for infectious disease susceptibility may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing resistance to infectious diseases in humans.
How similar studies have performed: Previous research has shown success in identifying genetic factors related to disease resistance in other organisms, suggesting potential for similar breakthroughs in this study.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Gibson, Amanda K — University of Virginia
- Study coordinator: Gibson, Amanda K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.