Investigating the genetic factors that increase the risk of developing breast cancer in the opposite breast after radiation treatment.
Official title: The Genetic Epidemiology of Radiation-Associated Contralateral Breast Cancer
Funded at Sloan-Kettering Inst Can Research · NIH-11050395 · Data updated 2026-11-12
This study is looking at how certain genes might affect the chances of women getting breast cancer in the other breast after they've had radiation treatment for their first breast cancer, so that doctors can make better treatment plans and help patients feel more informed about their options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 6, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $752,049 |
| NIH project number | 1R01CA289804-01A1 |
| Project ID | NIH-11050395 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include women who have been diagnosed with unilateral breast cancer and have received radiation therapy as part of their treatment.
✕Less likely to help
Patients who have not undergone radiation therapy for breast cancer or those with other types of cancer may not benefit from this research.
What this research studies
This research focuses on understanding how genetic factors influence the risk of developing contralateral breast cancer (CBC) in women who have undergone radiation therapy for primary breast cancer. By analyzing data from a large population-based study, the researchers aim to identify specific genetic variants that may increase susceptibility to CBC following radiation exposure. The study will utilize advanced techniques, including DNA sequencing and risk estimation models, to provide insights that could help tailor treatment plans for patients. Ultimately, the goal is to empower patients and healthcare providers with knowledge that can lead to better-informed decisions regarding cancer treatment and management.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatment strategies that minimize the risk of developing a second breast cancer in patients who have received radiation therapy.
How similar studies have gone: Previous research has shown promising results in identifying genetic risk factors for breast cancer, suggesting that this approach may yield valuable insights into radiation-associated risks as well.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Bernstein, Jonine L. — Sloan-Kettering Inst Can Research
- Study coordinator: Bernstein, Jonine L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.