Investigating the genetic factors of severe mental illnesses across diverse populations
1/3 Sequencing and Trans-Diagnostic Phenotyping of Severe Mental Illness in Diverse Populations
This study is looking at the genes of people with serious mental health conditions like schizophrenia, bipolar disorder, and severe depression, as well as healthy individuals, to find out how our DNA might play a role in these illnesses, which could help us understand them better and develop new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10694920 on NIH RePORTER |
What this research studies
This research aims to explore the genetic underpinnings of severe mental illnesses such as schizophrenia, bipolar disorder, and severe depression by analyzing DNA samples from over 150,000 individuals with these conditions and a similar number of healthy controls. The study will utilize advanced genomic techniques, including whole-exome sequencing and SNP-array genotyping, to identify genetic variations that may contribute to these disorders. By collaborating with the Regeneron Genomics Center, the research will ensure high-quality genomic assays and comprehensive data analysis. The findings could lead to better understanding and potential new treatments for severe mental illnesses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with schizophrenia, schizoaffective disorder, bipolar I disorder, or severe major depressive disorder.
Not a fit: Patients with mild or non-severe mental health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for patients with severe mental illnesses.
How similar studies have performed: Previous research in psychiatric genomics has shown promising results in understanding the genetic basis of mental illnesses, indicating that this approach has potential for success.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Sullivan, Patrick F — Univ of North Carolina Chapel Hill
- Study coordinator: Sullivan, Patrick F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.