Investigating the genetic factors of PTSD
Official title: Next steps for PTSD genomics: from loci to function
Funded at Mclean Hospital · NIH-11091592 · Data updated 2026-11-12
This study is looking at how our genes might play a role in post-traumatic stress disorder (PTSD) to help find better ways to diagnose and treat the condition, so people with PTSD can get the support they need.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mclean Hospital NIH-funded |
| Lab location | 1 site (Belmont, United States) |
| Project start | May 17, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $689,594 |
| NIH project number | 5R01MH133268-02 |
| Project ID | NIH-11091592 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with PTSD, particularly those who have experienced trauma.
✕Less likely to help
Patients who do not have PTSD or have not experienced significant trauma may not benefit from this research.
What this research studies
This research focuses on understanding the genetic basis of post-traumatic stress disorder (PTSD) by identifying specific genetic variants associated with the condition. Using advanced techniques like genome-wide association studies (GWAS) and multi-omic analyses, the team aims to link these genetic factors to molecular mechanisms in key brain regions involved in PTSD, such as the amygdala and hippocampus. Patients may benefit from insights that could lead to the development of reliable diagnostic biomarkers and targeted therapies for PTSD.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and personalized treatment options for individuals suffering from PTSD.
How similar studies have gone: Previous research has shown promise in identifying genetic factors related to PTSD, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Mclean Hospital
Belmont, United States Active
Researchers
- Principal investigator: Daskalakis, Nikolaos — Mclean Hospital
- Study coordinator: Daskalakis, Nikolaos
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.