Investigating the genetic factors of pain in head and neck cancer patients
Clinical study to evaluate the methylation signature of head and neck squamous cell carcinoma pain
This study is looking at how changes in DNA might affect the pain felt by people with head and neck cancer, and by collecting tissue samples and pain information from patients, researchers hope to find new ways to help manage that pain better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loma Linda University NIH-funded |
| Lab location | 1 site (Loma Linda, UNITED STATES) |
| Project ID | NIH-10913309 on NIH RePORTER |
What this research studies
This research focuses on understanding how changes in DNA methylation affect pain experienced by patients with head and neck squamous cell carcinoma (HNSCC). By enrolling patients and assessing their pain levels through validated questionnaires, researchers will collect cancer tissue samples to analyze the genetic markers associated with severe pain. The goal is to identify specific genes that are hypermethylated in these patients, which could lead to new treatment strategies using hypomethylating agents. This approach aims to bridge the gap between basic science and clinical application, ultimately improving pain management for HNSCC patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with head and neck squamous cell carcinoma who are experiencing severe pain.
Not a fit: Patients with head and neck cancer who do not experience significant pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective pain management strategies for patients suffering from head and neck cancer.
How similar studies have performed: Previous research has shown promise in exploring genetic factors related to cancer pain, suggesting that this approach could yield valuable insights.
Where this research is happening
Loma Linda, UNITED STATES
- Loma Linda University — Loma Linda, United States (Active)
Researchers
- Principal investigator: Viet, Chi T. — Loma Linda University
- Study coordinator: Viet, Chi T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.