Investigating the genetic factors of coronary artery disease using advanced genome sequencing techniques.
A paradigm for comprehensive genetic association studies of complex disease using pangenomic methods and local ancestry inference
This study is looking to better understand coronary artery disease by examining the DNA of about 55,000 people from different backgrounds, so we can find out how genetics play a role in this condition and help everyone, no matter their ancestry.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11009968 on NIH RePORTER |
What this research studies
This research aims to enhance our understanding of complex genetic diseases, particularly coronary artery disease, by utilizing comprehensive whole genome sequencing (WGS) methods. The study will develop a new analysis pipeline that leverages a diverse set of reference genomes, allowing for improved detection of genetic variations across different populations. By analyzing approximately 55,000 genomes, the research will focus on identifying genetic traits associated with coronary artery disease and related cardiometabolic risks, ultimately aiming to reduce ancestry bias in genetic studies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of coronary artery disease or those diagnosed with cardiometabolic conditions.
Not a fit: Patients without any genetic predisposition to coronary artery disease or those not belonging to diverse ancestry groups may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate genetic risk assessments and personalized treatment strategies for coronary artery disease.
How similar studies have performed: Previous research has shown promising results using similar genome sequencing approaches to uncover genetic factors in complex diseases.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Hall, Ira M — Yale University
- Study coordinator: Hall, Ira M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.