Investigating the genetic factors affecting heart structure and function related to heart failure.
Genetic Architecture of Cardiac Structure and Function and Its Impact on Heart Failure
This study is looking at how our genes can affect heart health, especially for people at risk of heart failure, by examining different genetic traits in various groups, including those with African ancestry, to help predict heart problems better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10873331 on NIH RePORTER |
What this research studies
This research focuses on understanding how genetic variations influence the structure and function of the heart, particularly in relation to heart failure (HF). By analyzing data from diverse population cohorts, including those with African ancestry, the study aims to identify both common and rare genetic variants that may contribute to cardiac abnormalities. The researchers will utilize advanced whole genome sequencing techniques to enhance the prediction of HF risk based on genetic predispositions. This approach seeks to provide a more comprehensive understanding of heart health and disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of heart disease, particularly those of African descent, as well as those experiencing cardiac abnormalities.
Not a fit: Patients without any genetic predisposition to heart disease or those who do not belong to the targeted demographic may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved risk prediction and personalized treatment strategies for heart failure patients.
How similar studies have performed: Previous research has successfully identified genetic factors related to heart conditions, suggesting that this approach has the potential for significant findings.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Yu, Bing — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Yu, Bing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.