Investigating the genetic factors affecting breast cancer treatment outcomes in Black patients
Official title: Project 1
Funded at Wayne State University · NIH-10879549 · Data updated 2026-11-12
This study is looking into why Black patients with a specific type of breast cancer don't do as well with treatment as White patients, and it hopes to find ways to create better, more personalized treatments for them by exploring the role of genetics and the immune system.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | September 5, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $244,657 |
| NIH project number | 1P20CA290450-01 |
| Project ID | NIH-10879549 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are Black patients diagnosed with HER2+ breast cancer.
✕Less likely to help
Patients who do not have HER2+ breast cancer or are not of African descent may not benefit from this research.
What this research studies
This research focuses on understanding why Black patients with HER2+ breast cancer experience poorer treatment outcomes compared to White patients. It examines the potential biological and genetic factors that may contribute to these disparities, utilizing a genetically diverse mouse model to control for tumor differences. By analyzing how the host's genetic background influences immune responses to targeted immunotherapies, the study aims to identify specific genomic loci linked to treatment success. This could lead to more effective and personalized treatment strategies for Black patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment outcomes for Black patients with HER2+ breast cancer.
How similar studies have gone: Other research has shown that understanding genetic factors can significantly improve treatment outcomes, suggesting this approach has potential for success.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Gibson, Heather Marie — Wayne State University
- Study coordinator: Gibson, Heather Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.