Investigating the genetic factors affecting bone mineral density in men.
Functional Dissection of the MARK3 GWAS Locus for Bone Mineral Density
This study is looking at how certain genes affect bone strength, especially in men and veterans who might be more likely to develop osteoporosis, to help find better ways to prevent and treat this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baltimore VA Medical Center NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10948073 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific genetic variations influence bone mineral density (BMD), particularly in men, including veterans who may be at higher risk for osteoporosis. By analyzing genetic data from large-scale studies, the researchers aim to identify causal genes linked to BMD and their roles in bone health. The study employs advanced mapping techniques to connect these genes to biological processes that regulate bone density, potentially leading to new insights into osteoporosis prevention and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are male veterans, especially those at risk for osteoporosis due to age or other factors.
Not a fit: Patients who are not male or do not have risk factors for osteoporosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating osteoporosis in men, particularly veterans.
How similar studies have performed: Previous research has successfully identified genetic factors associated with bone density, suggesting that this approach has the potential for meaningful discoveries.
Where this research is happening
Baltimore, United States
- Baltimore VA Medical Center — Baltimore, United States (Active)
Researchers
- Principal investigator: Clemens, Thomas L — Baltimore VA Medical Center
- Study coordinator: Clemens, Thomas L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.