Investigating the genetic diversity of Klebsiella bacteria to understand infection risks
Official title: Capsular locus deep sequencing to study Klebsiella populations
Funded at University of Michigan at Ann Arbor · NIH-10911962 · Data updated 2026-11-12
This study is looking at how different types of Klebsiella bacteria can settle in patients and potentially cause infections, with the hope of finding ways to prevent these infections for those who carry the bacteria.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 22, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $195,000 |
| NIH project number | 5R21AI176642-02 |
| Project ID | NIH-10911962 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients in intensive care units who are colonized by Klebsiella species.
✕Less likely to help
Patients who are not colonized by Klebsiella or those with no risk factors for infection may not benefit from this research.
What this research studies
This research focuses on understanding how different strains of Klebsiella bacteria colonize patients and how this colonization can lead to serious infections. By using advanced sequencing techniques, the study aims to identify the genetic variations among these strains, which may influence their ability to cause disease. Patients who are colonized by Klebsiella will be monitored to see how these diverse strains interact and whether certain genetic markers can predict the risk of developing infections. The ultimate goal is to develop strategies to prevent infections in patients who carry these bacteria.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for preventing Klebsiella infections in vulnerable patients.
How similar studies have gone: Previous research has shown that understanding the genetic diversity of bacterial populations can lead to significant advancements in infection control, suggesting this approach has potential for success.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Bachman, Michael Abbott — University of Michigan at Ann Arbor
- Study coordinator: Bachman, Michael Abbott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.