Investigating the genetic changes in lung cancer that lead to aggressive forms of the disease.
Uncovering Epigenetic and Transcriptional Drivers of Neuroendocrine Plasticity at Single-Cell Level in Patients with Small Cell Lung Cancer Transformation
This study is looking at how lung adenocarcinoma can change into a tougher form of lung cancer called small cell lung cancer, and it's for patients with mixed types of lung cancer to help find better treatments by understanding what makes these cancers different.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10994085 on NIH RePORTER |
What this research studies
This research focuses on understanding how lung adenocarcinoma can transform into small cell lung cancer, which is often more aggressive and resistant to treatment. By analyzing individual cancer cells using advanced sequencing techniques, the study aims to uncover the genetic and epigenetic factors that drive this transformation. Patients with mixed types of lung cancer will be studied to identify the mechanisms behind tumor diversity and treatment resistance. The findings could lead to better-targeted therapies for patients experiencing this type of cancer progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with lung adenocarcinoma that has transformed into small cell lung cancer.
Not a fit: Patients with early-stage lung cancer that has not undergone transformation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with small cell lung cancer and those with mixed lung cancer types.
How similar studies have performed: Other research has shown promising results in understanding cancer plasticity and treatment resistance, making this approach both relevant and potentially impactful.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Chan, Joseph Minhow — Sloan-Kettering Inst Can Research
- Study coordinator: Chan, Joseph Minhow
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.