Investigating the genetic changes in biliary cancer
Epigenetic Mechanisms of Biliary Epithelial Neoplasia
This study is looking at how changes in genes and proteins might lead to bile duct cancer, with the hope of finding new ways to treat or prevent this tough illness for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-11043627 on NIH RePORTER |
What this research studies
This research focuses on cholangiocarcinoma, a severe form of bile duct cancer that is becoming more common and currently lacks effective treatments. The study examines how genetic and epigenetic changes contribute to the development of this cancer, particularly through the role of specific enzymes that modify histones, which are proteins that help package DNA. By understanding these mechanisms, researchers aim to uncover new potential targets for treatment and prevention. Patients may benefit from insights that could lead to innovative therapies or preventive strategies against this aggressive cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cholangiocarcinoma or those at high risk for developing this type of cancer.
Not a fit: Patients with other types of cancer unrelated to biliary epithelial neoplasia may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options or preventive measures for patients with biliary cancer.
How similar studies have performed: Previous research has shown promising results in understanding the role of epigenetic mechanisms in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Wu, Tong — Tulane University of Louisiana
- Study coordinator: Wu, Tong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.