Investigating the genetic causes of severe mental illness across diverse populations
2/3 Sequencing and Trans-Diagnostic Phenotyping of Severe Mental Illness in Diverse Populations
This study is looking at how our genes might play a role in serious mental health conditions like schizophrenia, bipolar disorder, and severe depression, and it's inviting people with these conditions to help researchers find clues that could lead to better treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10695186 on NIH RePORTER |
What this research studies
This research aims to understand the genetic factors contributing to severe mental illnesses such as schizophrenia, bipolar disorder, and severe depression. By analyzing the DNA of over 150,000 individuals with these conditions and a similar number of healthy controls, the study will utilize advanced genomic techniques to identify genetic variations. Patients will be recruited from various clinical settings, and their genetic data will be compared to uncover patterns that may inform future treatments. The collaboration with Regeneron Genomics Center will facilitate the genomic assays needed for this large-scale project.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals diagnosed with schizophrenia, schizoaffective disorder, bipolar I disorder, or severe major depressive disorder.
Not a fit: Patients with mild or non-severe mental health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for individuals suffering from severe mental illnesses.
How similar studies have performed: Previous research in psychiatric genomics has shown promise in identifying genetic factors associated with mental illnesses, indicating that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Charney, Alexander W — Icahn School of Medicine at Mount Sinai
- Study coordinator: Charney, Alexander W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.