Investigating the genetic causes of fetal brain abnormalities
Genomics and functional dissection of fetal brain abnormalities using a prenatal cohort
This study is looking at brain problems in unborn babies that can be seen on ultrasounds, and it aims to find out what genetic factors might cause these issues, so families can get better information and support.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10908283 on NIH RePORTER |
What this research studies
This research focuses on understanding fetal brain abnormalities (FBA), which are common issues detected during prenatal ultrasounds. By combining ultrasound imaging with advanced genetic analysis, the team aims to identify the genetic factors that contribute to these abnormalities. The study utilizes prenatal exome sequencing and zebrafish models to explore the genetic variations associated with FBA, ultimately aiming to improve diagnostic capabilities and provide better counseling for affected families.
Who could benefit from this research
Good fit: Ideal candidates for this research include expectant parents whose fetuses have been diagnosed with brain abnormalities through ultrasound.
Not a fit: Patients whose fetuses do not exhibit any brain abnormalities or other related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods for fetal brain abnormalities, allowing for better prenatal care and family counseling.
How similar studies have performed: Previous research using similar genetic approaches has shown promise in diagnosing complex fetal conditions, indicating that this study builds on established methodologies.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Vora, Neeta L — Univ of North Carolina Chapel Hill
- Study coordinator: Vora, Neeta L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.