Investigating the genetic causes of Alzheimer's disease using advanced models and techniques
Official title: Combinatorial Perturbation with Multi-Omics Readout to Dissect Etiology of Alzheimer's Disease Using Stem Cell and In Vivo Models
Funded at Stanford University · NIH-11061159 · Data updated 2026-11-12
This study is looking at how different genes work together to affect Alzheimer's disease in older adults, using special tools to better understand these interactions, which could eventually help develop new ways to diagnose and treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | March 15, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $619,681 |
| NIH project number | 1R01AG091819-01 |
| Project ID | NIH-11061159 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who are at risk for or affected by Alzheimer's disease.
✕Less likely to help
Patients under the age of 65 or those with non-neurodegenerative conditions may not benefit from this research.
What this research studies
This research aims to understand the complex genetic interactions that contribute to Alzheimer's disease (AD), particularly in older adults. By utilizing innovative tools that allow for the precise manipulation of multiple genetic risk factors, the study will explore how these factors interact in human stem cell models and in a mouse model of AD. The approach combines advanced gene-editing techniques with multi-omics analysis to provide a comprehensive view of the biological processes involved in AD. Patients may benefit from insights gained that could lead to new diagnostic and therapeutic strategies for Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to novel targets for diagnosing and treating Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in using genetic manipulation and multi-omics approaches to understand complex diseases, indicating potential success for this novel approach.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Cong, Le — Stanford University
- Study coordinator: Cong, Le
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.