Investigating the genetic basis of unique human traits
From a Long List to Causal Variants: High-Throughput Gene Regulatory Assays in Developing Tissues
This study is looking at the unique parts of our DNA that make us human, to help us understand how they might affect our health and risk for diseases, which could ultimately benefit patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10864991 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic factors that contribute to traits unique to humans, which are not found in our closest relatives like chimpanzees. The team will explore the less-studied 95% of the human genome to identify rapidly evolving regions that may play a role in human adaptations and disease susceptibility. By using high-throughput gene regulatory assays, they aim to functionally characterize these genomic elements, potentially revealing new insights into human biology and health. Patients may benefit from this research as it could lead to a better understanding of genetic risks associated with various diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with a family history of genetic diseases or those interested in understanding their genetic predispositions.
Not a fit: Patients with well-defined genetic conditions that are already understood may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic factors influencing human health and disease, leading to improved prevention and treatment strategies.
How similar studies have performed: While research into the functional aspects of the human genome is ongoing, this approach of focusing on the less-conserved regions is relatively novel and has not been extensively tested.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Lowe, Craig Barrett — Duke University
- Study coordinator: Lowe, Craig Barrett
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.