Investigating the genetic and environmental factors that influence dementia risk in diverse populations
DNA Methylation,Genetics, and Modifiable Risk Factors of Dementia in a Nationally Representative, Multi-Ethnic Cohort
This study is looking at how changes in our DNA and lifestyle choices might affect the risk of Alzheimer's and related dementias in older adults from different backgrounds, to help us understand what factors could help reduce that risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10814383 on NIH RePORTER |
What this research studies
This research focuses on understanding how DNA methylation and various modifiable risk factors contribute to the risk of Alzheimer's disease and related dementias (ADRD) in a diverse group of aging adults. By analyzing existing genetic and epigenetic data alongside lifestyle and environmental factors, the study aims to identify key contributors to dementia risk, particularly in populations that are disproportionately affected. The research will utilize a nationally representative sample to ensure that findings are applicable across different racial and ethnic groups, and will explore how educational attainment and geographic factors may influence these risks.
Who could benefit from this research
Good fit: Ideal candidates for this research include aging adults from diverse racial and ethnic backgrounds, particularly those with a family history of dementia or other risk factors.
Not a fit: Patients who are younger than 21 years old or do not have any risk factors for dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted prevention strategies and interventions that reduce the risk of dementia in vulnerable populations.
How similar studies have performed: Previous research has shown promising results in understanding the genetic and environmental factors influencing dementia risk, suggesting that this approach could yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Bakulski, Kelly — University of Michigan at Ann Arbor
- Study coordinator: Bakulski, Kelly
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.