Investigating the functions of genes linked to neurodevelopmental and psychiatric disorders using stem cells
Official title: Assay and Data Generation Center (ADGC) for the Model of iPSC-derived Neurons for NPD (MiNND)
Funded at Rutgers Biomedical and Health Sciences · NIH-11094814 · Data updated 2026-11-12
This study is looking at how certain genes linked to conditions like autism and bipolar disorder work in the brain, using special cells to create neurons, so we can better understand these disorders and hopefully find new treatments that could help patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | May 17, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,757,999 |
| NIH project number | 5RM1MH133065-03 |
| Project ID | NIH-11094814 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with neurodevelopmental or psychiatric disorders, particularly those with a family history of such conditions.
✕Less likely to help
Patients with neurodevelopmental or psychiatric disorders that are not linked to the specific genes being studied may not receive benefit from this research.
What this research studies
This research focuses on understanding the biological functions of genes associated with neurodevelopmental and psychiatric disorders, such as autism and bipolar disorder. By using induced pluripotent stem cells (iPSCs) to create neurons, the team will conduct large-scale assays to study up to 200 risk genes simultaneously. This approach aims to overcome previous limitations by providing a more comprehensive view of how these genes contribute to disease mechanisms. Patients may benefit from insights that could lead to new treatments or interventions based on genetic findings.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurodevelopmental and psychiatric disorders.
How similar studies have gone: Other research has shown promise in using similar approaches to study genetic contributions to psychiatric disorders, indicating potential for success.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Pang, Zhiping P. — Rutgers Biomedical and Health Sciences
- Study coordinator: Pang, Zhiping P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.