Investigating the Foxi3 gene's role in craniofacial microsomia
Official title: The role of the Foxi3 transcription factor in craniofacial microsomia
Funded at Baylor College of Medicine · NIH-11005767 · Data updated 2026-11-12
This study is looking into craniofacial microsomia, a condition that affects how some people's faces develop, and it aims to learn more about the genes involved so that we can find better ways to diagnose and treat those who have it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | March 15, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $583,053 |
| NIH project number | 5R01DE032244-03 |
| Project ID | NIH-11005767 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with craniofacial microsomia or related craniofacial abnormalities.
✕Less likely to help
Patients with craniofacial conditions not related to the pharyngeal arches may not benefit from this research.
What this research studies
This research focuses on understanding craniofacial microsomia (CFM), a common birth defect affecting the development of facial structures. The team will study the Foxi3 transcription factor, which is crucial for the proper formation of the first and second pharyngeal arches. By using animal models, they aim to uncover the molecular mechanisms behind CFM and identify genetic variants linked to this condition. The findings could lead to better diagnostic and therapeutic strategies for affected individuals.
Why it matters
Potential benefit: If successful, this research could provide insights that lead to improved treatments and interventions for patients with craniofacial microsomia.
How similar studies have gone: Previous research has shown promising results in understanding genetic factors related to craniofacial defects, indicating that this approach has potential for success.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Groves, Andrew K — Baylor College of Medicine
- Study coordinator: Groves, Andrew K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.