Investigating the features of HIV reservoir cells at a single-cell level
Single-cell Analysis of Glycomic and Proteomic Features of the HIV Reservoir
This study is looking at the different types of HIV cells that stick around even when people are on treatment, to help us understand why the virus can come back after stopping medication, and it could lead to new ways to help find a cure for HIV.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wistar Institute NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10672296 on NIH RePORTER |
What this research studies
This research focuses on understanding the different types of HIV reservoir cells that persist despite antiretroviral therapy (ART). By analyzing these cells at a single-cell level, the study aims to identify both latent and transcriptionally-active reservoir cells, which are crucial for understanding HIV rebound after treatment interruption. The researchers will explore the role of cell surface proteins and glycans in these cells, as glycans are important for various cellular processes and could serve as biomarkers for HIV persistence. This comprehensive analysis may lead to new insights into HIV biology and potential strategies for achieving a cure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy.
Not a fit: Patients who are not living with HIV or those who are not on antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for targeting HIV reservoir cells, potentially contributing to a functional cure for HIV.
How similar studies have performed: Previous research has shown promise in characterizing HIV reservoir cells, but this approach focusing on glycans is relatively novel.
Where this research is happening
Philadelphia, United States
- Wistar Institute — Philadelphia, United States (Active)
Researchers
- Principal investigator: Abdel Mohsen, Mohamed — Wistar Institute
- Study coordinator: Abdel Mohsen, Mohamed
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.