Investigating the endometrial-myometrial junction in adenomyosis to discover new treatments
Single cell analytics and drug discovery at the endometrial-myometrial junction in symptomatic adenomyosis
This study is looking at adenomyosis, a painful condition that affects some women, to better understand how it works at a tiny level and to find new treatments that could help ease symptoms and improve daily life.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10871250 on NIH RePORTER |
What this research studies
This research focuses on adenomyosis, a painful uterine condition where endometrial cells invade the myometrium, causing inflammation and severe symptoms like heavy menstrual bleeding and dysmenorrhea. By examining these cells at a single-cell level, the research aims to understand the underlying mechanisms of the disease and identify potential new therapies. The approach includes advanced bioinformatics and drug discovery techniques to develop targeted treatments that could alleviate symptoms and improve the quality of life for affected women.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with adenomyosis who experience severe symptoms such as dysmenorrhea and heavy menstrual bleeding.
Not a fit: Patients who do not have adenomyosis or those who have already undergone a hysterectomy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly reduce the symptoms of adenomyosis and enhance the well-being of patients.
How similar studies have performed: Previous research has shown promise in using single-cell analytics for understanding complex diseases, suggesting that this approach could yield valuable insights for adenomyosis.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Giudice, Linda C — University of California, San Francisco
- Study coordinator: Giudice, Linda C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.