Investigating the effects of toxic chemicals on zebrafish development and health.
Using Zebrafish to Model Developmental and Multigenerational Volatile Organic Compound Toxicity
This study is looking at how two harmful chemicals, TCE and PERC, affect the growth and health of zebrafish, which can help us understand the potential risks these chemicals might pose to human health, especially for conditions like birth defects and brain diseases.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Auburn University at Auburn NIH-funded |
| Lab location | 1 site (Auburn, UNITED STATES) |
| Project ID | NIH-10291528 on NIH RePORTER |
What this research studies
This research explores how exposure to harmful chemicals, specifically trichloroethylene (TCE) and tetrachloroethylene (PERC), affects the development and health of zebrafish. By using zebrafish as a model organism, the study aims to understand the immediate and long-term impacts of these volatile organic compounds on growth, behavior, and potential genetic changes across generations. The research involves controlled experiments to observe how these chemicals are metabolized by zebrafish and how this metabolism influences toxicity. The findings could provide insights into the risks posed by these chemicals to human health, particularly regarding congenital defects and neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals concerned about the effects of environmental toxins on health, particularly those with a family history of congenital defects.
Not a fit: Patients who are not affected by or do not have concerns related to environmental toxins or congenital defects may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of congenital defects and other health issues linked to environmental toxins.
How similar studies have performed: Previous research has shown that using zebrafish to model the effects of environmental toxins can yield valuable insights, indicating that this approach has been successful in similar studies.
Where this research is happening
Auburn, UNITED STATES
- Auburn University at Auburn — Auburn, United States (Active)
Researchers
- Principal investigator: Horzmann, Katharine Ann Marie — Auburn University at Auburn
- Study coordinator: Horzmann, Katharine Ann Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.