Investigating the effects of synthetic cooling agents in e-cigarettes
Official title: The abuse liability, topography and toxicology of ice flavors and non-menthol synthetic cooling agents in e-cigarette products
Funded at Ohio State University · NIH-10895282 · Data updated 2026-11-12
This study is looking at how new cooling ingredients in e-cigarettes, which don’t taste like mint, might change how appealing and safe they are for young adult vapers, as they try different e-liquids and share their puffing habits and any health effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $712,798 |
| NIH project number | 5R01CA276696-02 |
| Project ID | NIH-10895282 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are young adult vapers aged 21-29 who regularly use e-cigarettes.
✕Less likely to help
Patients who do not use e-cigarettes or are not within the specified age range may not benefit from this research.
What this research studies
This research explores how synthetic cooling agents, which provide a cooling sensation without mint flavor, affect the appeal and safety of e-cigarettes. The study will involve young adult vapers who will participate in a crossover trial, using specially prepared e-liquids with and without these cooling agents. Researchers will measure puffing behavior and toxicity levels to understand the potential risks associated with these products. The goal is to provide insights into how these agents influence vaping habits and health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and regulation of e-cigarette products, ultimately improving user safety.
How similar studies have gone: While research on e-cigarettes is ongoing, this specific investigation into synthetic cooling agents is novel and has not been extensively studied before.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Tackett, Alayna Pauline — Ohio State University
- Study coordinator: Tackett, Alayna Pauline
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.